I'm a left handed artist. In printmaking it means that I need to throw out* the right handed knives that come with most sets and get a special left-handed or duel-bladed knife for myself. A typical right handed style blade is on the left and on the right is a duel sided pointed blade that works when held in both the left and the right hand. Very useful little tool that had to be special ordered.
There are lots of little challenges to being a left handed artist. The biggest one for me was avoiding smearing drawings with the side of my hand. Maybe that is one reason why I got into printmaking because there is no risk of smearing my work. Just a few special tools and tweaks and I am all set.
* Really I save them for students whenever I teach instead of throwing them out. But I can't use them effectively.